Studies in the biochemistry of micro-organisms. 106. Metabolites of Alternaria tenuis auct.: the structure of tenuazonic acid.
نویسنده
چکیده
Chibnall, A. C., Mangan, J. L. & Rees, M. W. (1958b). Biochem. J. 68, 114. Chibnall, A. C. & Rees, M. W. (1951). Biochem. J. 48, xlvii. Chibnall, A. C. A Rees, M. W. (1958). Biochem. J. 68, 105. Clayton, R. A. & Strong, F. M. (1954). Analyt. Chem. 26, 1362. Conway, E. J. (1935). Biochem. J. 29, 2755. Craig, L. C., Gregory, J. D. & Hausmann, W. (1950). Anadyt. Chem. 22, 1462. Craig, L. C., Konigsberg, W. & Hill, R. J. (1958). In Amino Acid8 and Peptides with Antimetabolic Activity, p. 226. London: J. and A. Chur¢hill Ltd. Craig, L. C., Weisiger, J. R., Hausmann, W. & Harfenist, E. J. (1952). J. biol. Chem. 199, 259. Crawhall, J. C. & Elliott, D. F. (1955). Biochem. J. 61, 264. Flynn, F. V. & de Mayo, P. (1951). Lancet, 261, 235. King, F. E. & Spensley, P. C. (1950). J. chem. Soc. p. 3159. Lockhart, I. M. & Abraham, E. P. (1954). Biochem. J. 58, 633. Lockhart, I. M., Abraham, E. P. & Newton, G. G. F. (1955). Biochem. J. 61, 534. Lyttle, D. A., Jensen, E. H. & Struck, W. A. (1952). Analyt. Chem. 24, 1843. Markham, R. (1942). Biochem. J. 36, 790. Newton, G. G. F. & Abraham, E. P. (1950). Biochem. J. 47, 257. Newton, G. G. F. & Abraham, E. P. (1953a). Biochem. J. 53, 597. Newton, G. G. F. & Abraham, E. P. (1953b). Biochem. J. 53, 604. Newton, G. G. F. & Abraham, E. P. (1954). Biochem. J. 58, 103. Nystrom, R. F., Chaikin, S. W. & Brown, W. G. (1949). J. Amer. chem. Soc. 71, 3245. Partridge, S. M. (1948). Biochem. J. 42, 238. Rees, M. W. (1958). Biochem. J. 68, 118. Smith, I. (1953). Nature, Lond., 171, 43. Sorensen, S. P. L. (1905). Bull. Soc. chim. Fr., 33, 1052. S6rensen, S. P. L., Hoyrup, M. & Andersen, A. C. (1911). Hoppe-Seyl. Z. 76, 44. Swallow, D. L. & Abraham, E. P. (1957). Biochem. J. 65, 39P. Swallow, D. L. & Abraham, E. P. (1958). Biochem. J. 70, 364. Synge, R. L. M. (1951). Biochem. J. 49, 642. Underwood, J. C. & Rockland, L. B. (1954). Analyt. Chem. 26, 1553. Weisiger, J. R., Hausmann, W. & Craig, L. C. (1955a). J. Amer. chem. Soc. 77, 731. Weisiger, J. R., Hausmann, W. & Craig, L. C. (1955b). J. Amer. chem. Soc. 77, 3123. Woiwod, A. J. (1949). J. gen. Microbiol. 3, 312. Wright, B. E. & Stadtman, T. C. (1956). J. biol. Chem. 210, 863.
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ورودعنوان ژورنال:
- The Biochemical journal
دوره 72 2 شماره
صفحات -
تاریخ انتشار 1959